Abstracto

Clinical trials and overactive bladder: lessons learned

Ariana L Smith, Alan J Wein

Overactive bladder is a prevalent, costly and bothersome condition that greatly affects quality of life. Several therapeutic interventions have been introduced over the years – some conservative and others more invasive – to address the needs of this patient population. Scientific evidence to support these interventions varies widely with respect to number of clinical trials as well as the caliber of these trials to evaluate efficacy. Comparative effectiveness of these interventions is vastly understudied, as are patient-reported outcomes and understanding of what matters most to patients. This article will review the available data and level of evidence for the therapeutic alternative used in the contemporary management of overactive bladder, highlight recent advances in research and address the ongoing challenges in evolving care for this condition.