Abstracto

Role of HIPK2 in the Physiology of Nervous System

Justin Twain

HIPK2 is a transformative preserved serine/threonine kinase with multifunctional jobs in pressure reaction, undeveloped turn of events and obsessive circumstances, like malignant growth and fibrosis. The heterogeneity of its interactors and targets makes HIPK2 action firmly subject to the phone setting, and permits it to tweak various flagging pathways, eventually directing cell destiny and multiplication. Both the central and peripheral nervous systems express HIPK2, and mice with its genetic ablation suffer neurological defects. In addition, HIPK2 plays a crucial role in the pathogenesis of neurological disorders by participating in processes and pathways like the endoplasmic reticulum stress response and protein aggregate accumulation. The implications for the pathogenesis of neurological disorders and HIPK2's potential as a therapeutic target and diagnostic or prognostic marker are highlighted in this review of the data regarding its role in neuronal development, survival, and homeostasis.