Clinical traits and underlying pathophysiological mechanisms of complex regional pain syndromes

Sandra P Koffler

Aim of the work

To study relationship between clinical pattern of complex regional pain syndromes (CRPS) and inflammatory and sympathetic parameters.

Materials and methods

Twenty one CRPS patients and 15 healthy controls were examined. Clinical data, sympathetic skin response (SSR), TNF and normetanephrine were evaluated.


Fourteen patients had increased serum TNF which showed significant relationship with some clinical parameters. Three patients had increased normetanephrine. Mean SSR latency was shortened in patients. No significant relationship between SSR and sweating manifestations and no correlation between serum normetanephrine, SSR, and serum TNF were found.


Inflammation plays a major role and SSR is enhanced in CRPS.